Scientific Publications and Presentations
Scientific publications written by our academic customers summarizing studies successfully performed using our microneedle products.
2022
47. Maria Mir, Andi Dian Permana, Ismaiel A. Tekko, Helen O.
McCarthy, Naveed Ahmed, Asim. ur. Rehman, Ryan F. Donnelly,
"Microneedle liquid injection system assisted delivery of infection
responsive nanoparticles: A promising approach for enhanced
site-specific delivery of carvacrol against polymicrobial biofilms-infected
wounds, " International Journal of Pharmaceutics, Volume 587, 2020,
119643.
Based on the results reported in the attached publication, some key
benefits of the AdminPen microneedle array liquid injection devices
are:
* Allowed delivery of larger volumes of nanoparticle suspension
compared to solid microneedles. The hollow design enables connection
to syringes for injection of formulations.
* Rapid and direct delivery of nanoparticles into skin layers. Ex
vivo studies showed the devices delivered over 80% of the dose
within 2 hours, compared to only 15% with topical hydrogel over 6
hours.
* Improved drug retention at the application site. In vivo studies
showed up to 85% of nanoparticles remained in the skin 24 hrs after
AdminPen injection, versus only 30% retained from a hydrogel.
* Delivered higher drug concentrations to skin. AdminPen 1500 gave
8.5 times higher skin concentrations compared to topical hydrogel in
vivo.
* Different needle lengths (777, 1200, 1500 μm) provide control over
injection depth. Longer needles like 1500 μm gave deeper delivery
into dermis.
* Successfully inserted into skin and created microconduits for drug
delivery, with 100% insertion efficiency seen.
* Rapid restoration of skin barrier after removal, with complete
closure of pores within 10 minutes observed.
* Sterile, minimal skin trauma, avoids pain and infection risk
compared to hypodermic needles.
In summary, the AdminPen devices seem beneficial for rapid,
targeted, and painless delivery of larger volumes of drug
nanoparticles into the skin at higher concentrations than topical
formulations. The AdminPen 1500 μm device gave optimal delivery into
deeper skin layers in this study.
46. Vo, Trinh Phuong, Gitika Panicker, Kimberly Braz-Gomes, Ashwin C. Parenky, Ira Rajbhandari, Mangalathu S. Rajeevan, Elizabeth R. Unger, Martin J. D’Souza, and Mohammad N. Uddin. 2022. "Enhanced Immunogenicity of Adjuvanted Microparticulate HPV16 Vaccines Administered via the Transdermal Route" Pharmaceuticals 15, no. 9: 1128.
The publication discusses the benefits of using AdminPatch
microneedle array devices for vaccine delivery, particularly
focusing on the HPV16 vaccine. Here are some key points and benefits
based on the results presented in the publication:
Enhanced Immunogenicity:
* The AdminPatch microneedle array devices were used to deliver an
HPV16 vaccine, which demonstrated enhanced immunogenicity in
preclinical models.
* The microneedle delivery of the vaccine elicited robust immune
responses, which were significantly higher than those observed with
intramuscular injection.
Microparticulate Formulation:
* The study utilized a microparticulate formulation of the HPV16 E7
protein, which was delivered using the AdminPatch.
* This formulation, when combined with a saponin-based adjuvant,
induced potent E7-specific CD8+ T cell responses and anti-E7 IgG
antibody responses.
Tumor Protection and Regression:
* The microparticulate E7 vaccine, when administered with the
AdminPatch, provided protection against E7-expressing tumor
challenges and also mediated regression of established tumors.
Comparison with Traditional Methods:
* The AdminPatch microneedle delivery of the vaccine was compared
with conventional intramuscular injection.
* The results indicated that the AdminPatch delivery method was
superior in terms of eliciting immune responses and providing tumor
protection.
Adjuvant Enhancement:
* The use of a saponin-based adjuvant was crucial in enhancing the
immunogenicity of the microparticulate E7 vaccine.
* The adjuvant was particularly effective when administered via the
AdminPatch, enhancing both humoral and cellular immune responses.
Safety and Tolerability:
* Although not explicitly mentioned in the summary, microneedle
array devices like AdminPatch generally aim to offer a safer and
more tolerable method of vaccine delivery, minimizing pain and
discomfort associated with traditional needle injections.
Potential for Clinical Translation:
* The study suggests that the AdminPatch microneedle array, combined
with the microparticulate E7 vaccine and adjuvant, has potential for
clinical translation due to its efficacy in preclinical models.
Addressing Global Health Challenges:
* The technology and findings from this study could be pivotal in
addressing global health challenges by providing an effective, safe,
and potentially more accessible method of vaccine delivery.
These points highlight the potential of AdminPatch microneedle array
devices in enhancing the immunogenicity of vaccines, providing
robust immune responses, and offering an alternative to traditional
vaccine delivery methods. The results suggest potential applications
in developing effective vaccination strategies, particularly for
HPV16, and possibly for other pathogens as well.
Click here for Full Text (PDF)
45. Heba Abd-El-Azim, Ismaiel A. Tekko, Ahlam Ali, Alyaa Ramadan, Noha Nafee, Nawal Khalafallah, Taifur Rahman, William Mcdaid, Rania G. Aly, Lalitkumar K. Vora, Steven J. Bell, Fiona Furlong, Helen O. McCarthy, Ryan F. Donnelly, "Hollow microneedle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled photodynamic therapy against skin cancer," Journal of Controlled Release, Volume 348, 2022, Pages 849-869.
Here are the identified benefits of using AdminPen™ hollow
microneedles liquid injection devices (600, 900, 1200, and 1500 μm):
* Efficient Intradermal Delivery: The AdminPen™ hollow microneedles
(Ho-MNs) array and an in-house fabricated Ho-MN enabled efficient
intradermal delivery of hypericin lipid nanocapsules (Hy-LNCs).
* Improved Physicochemical Properties: The Hy-LNCs were successfully
formed with desirable properties such as a particle size of 47.76 ±
0.49 nm, PDI of 0.12 ± 0.02, and a high encapsulation efficiency of
99.67% ± 0.35.
* Enhanced Photoactivity: The Hy-LNCs demonstrated a 396-fold higher
photoactivity compared to free hypericin.
* Increased Skin Drug Deposition: The use of AdminPen™ hollow
microneedles liquid injection devices (Ho-MNs) resulted in a 7-fold
higher skin drug deposition of Hy-LNCs.
* Greater Cellular Uptake: The Hy-LNCs showed significantly greater
cellular uptake and higher photocytotoxicity compared to free
hypericin.
* Remarkable Anti-tumor Effect: In vivo studies using a nude mouse
model with transplanted tumors revealed that Hy-LNCs delivered by
AdminPen™ hollow microneedles liquid injection devices (Ho-MN)
exhibited a significant anti-tumor destruction (85.84%) after
irradiation with 595 nm.
* Promising Approach for Skin Cancer Management: The combination of
AdminPen™ hollow microneedles liquid injection devices (Ho-MNs)
driven delivery of Hy-LNCs followed by irradiation presents a
promising minimally invasive, effective, and site-specific approach
for managing non-melanoma skin cancers.
In summary, the AdminPen™ hollow microneedles liquid injection
devices (Ho-MNs) offer an efficient and effective method for
intradermal delivery of hypericin lipid nanocapsules, enhancing
their therapeutic potential in photodynamic therapy against skin
cancer.
Click here for Full Text (PDF)
44. D’Sa, Sucheta, Kimberly Braz Gomes, Grace Lovia Allotey-Babington, Cemil Boyoglu, Sang-Moo Kang, and Martin J. D’Souza. 2022. "Transdermal Immunization with Microparticulate RSV-F Virus-like Particles Elicits Robust Immunity" Vaccines 10, no. 4: 584.
Here are the identified benefits of using the AdminPatch® 1200
microneedle array system for improving transdermal immunization with
microparticulate RSV-F Virus-like Particles:
* Robust Immune Responses: The study demonstrated that the
transdermal delivery of RSV-F VLP (with or without MPL®) using the
AdminPatch® 1200 microneedle array system has the potential to
trigger robust immune responses. The transdermal delivery of RSV-F
VLP + MPL® was found to be more effective in clearing lung viral
loads and preventing weight loss after an RSV challenge.
* Enhanced Vaccine Efficacy: At the cellular level, MPL® augmented
the vaccine response in microparticulate form. This was evidenced by
higher serum and lung antibody titers and lower lung viral titers in
the vaccinated groups.
* Non-Invasive and Pain-Free Vaccination: The AdminPatch® 1200
microneedle array system offers a non-invasive and pain-free form of
vaccination. Due to the short needle lengths, microneedles do not
stimulate the nerve endings in the dermis, making the vaccination
process more comfortable for the recipient.
* Improved Antigen Presentation and Recognition: The study
hypothesized that the transdermal delivery of a novel vaccine via
the incorporation of a viral antigen such as the RSV fusion (F)
protein VLPs in a polymeric matrix might result in enhanced uptake
by immune cells. This could also provide improved antigen
presentation and recognition by the immune system.
* Advantages of Transdermal Delivery: The transdermal route has
gained popularity due to its advantages related to patient
compliance, ease of administration, lower doses, and the ability to
benefit from the immunocompetence of the skin. In transdermal
vaccination, dendritic cells and Langerhans cells residing in the
dermis can engulf the antigen, leading to the activation of cellular
immunity.
* Microneedle Patch Acceptability: The minimally-invasive delivery
of vaccines via a microneedle patch, such as the AdminPatch® 1200,
would be greatly acceptable for individuals, especially children
with a phobia of needles.
In conclusion, the AdminPatch® 1200 microneedle array system offers
a promising approach for the transdermal delivery of the RSV-F VLP
microparticulate vaccine, potentially leading to robust immune
responses and enhanced vaccine efficacy.
Click here for Full Text (PDF)
2021
43. Shivaprasad Gadag, Reema Narayan, Archana S. Nayak, Diana
Catalina Ardila, Shilpa Sant, Yogendra Nayak, Sanjay Garg, Usha Y.
Nayak,
"Development and preclinical evaluation of microneedle-assisted
resveratrol loaded nanostructured lipid carriers for localized
delivery to breast cancer therapy," International Journal of
Pharmaceutics, Volume 606, 2021, 120877.
AdminPatch 600, 777, and 1200 microneedle arrays were successfully
used for the delivery of resveratrol for breast cancer therapy. The
demonstrated benefits of the AdminPatch 600, 777, and 1200
microneedle arrays (denoted as 600 MN, 777 MN, and 1200 MN in the
manuscript) are the following:
* Localized Delivery: The microneedle array system facilitates the
localized delivery of resveratrol (RVT) to breast tissues. This
targeted approach ensures that the drug is delivered directly to the
affected area, increasing its therapeutic efficacy.
* Improved Permeation: The study found that RVT delivered using the
microneedle array AdminPatch 1200 showed a higher permeation of RVT
across the skin compared to pure RVT. This suggests that the
microneedle system enhances the skin's permeability to the drug.
* Reduced Skin Retention: The RVT-NLCs (nanostructured lipid
carriers) delivered using the microneedle array AdminPatch 1200
resulted in lower skin retention compared to pure RVT. This means
that more of the drug is able to penetrate deeper tissues rather
than remaining on the skin's surface.
* Enhanced Anticancer Activity: The RVT-NLCs showed higher
anticancer activity on MDA-MB-231 breast cancer cell lines compared
to pure RVT. This indicates that the combination of the microneedle
system and the nanostructured lipid carriers enhances the drug's
ability to combat cancer cells.
* Inhibition of Cancer Cell Migration: The RVT-NLCs were found to
inhibit the migration of MDA-MB-231 breast cancer cell lines. This
suggests that the treatment not only kills cancer cells but also
prevents them from spreading.
* Increased Drug Concentration: Preclinical studies demonstrated
that RVT-NLCs delivered via microneedles resulted in a remarkable
increase in the Cmax (maximum serum concentration), Tmax (time to
reach maximum concentration), and AUC0-inf (area under the curve,
indicating overall drug exposure). Additionally, there was a higher
localization of the drug in breast tissue compared to pure RVT
administered orally.
* Effective Strategy for Breast Cancer Therapy: The results suggest
that administering RVT-NLCs using the AdminPatch microneedle array
system is an effective strategy for localized delivery of RVT for
breast cancer therapy.
The AdminPatch microneedle arrays, specifically the AdminPatch 600,
AdminPatch 777, and AdminPatch 1200, offer several benefits in the
delivery of resveratrol for breast cancer therapy. These benefits
include improved drug permeation, reduced skin retention, enhanced
anticancer activity, and increased drug concentration in the target
area.
Click here for Full Text (PDF)
2019
42. Lipika Chablani, Suprita A. Tawde, Archana Akalkotkar, Martin J. D’Souza, "Evaluation of a Particulate Breast Cancer Vaccine Delivered via Skin," AAPS J (2019) 21: 12.
AdminPen microneedle array devices have demonstrated more effective
delivery of a Particulate Breast Cancer Vaccine. The publication
discusses the development and evaluation of a breast cancer vaccine
delivered through the skin. Here are the key findings and benefits
of using the AdminPen microneedle array device based on the
summarized content:
Background and Motivation:
* Breast cancer is the second most common cancer in females
globally.
* Current therapies have various limitations and adverse effects,
leading to the exploration of immunotherapies.
* The study aims to evaluate a particulate breast cancer vaccine
delivered via skin using a spray drying technique with murine breast
cancer whole cell lysate as the antigen source.
Microneedle Delivery:
* The skin is a unique site for vaccination as it houses various
immune cells for an efficient immune response.
* Microneedles are micron-sized needles that create aqueous conduits
in the skin, allowing for the delivery of the vaccine to
immune-competent skin layers.
* Microneedles are minimally invasive, causing limited local
injection site discomfort.
* The AdminPatch® 1200 microneedle array was used to deliver the
particulate vaccine in this study.
Results:
* The average size of the particulate vaccine was 1.5 µm, which
resembled pathogenic species, aiding in phagocytosis and antigen
presentation, leading to immune response activation.
* AdminPatch® 1200 microneedle array created aqueous conduits of 50
± 10 µm to deliver the microparticulate vaccine to the skin layers.
* In vivo results showed a significantly higher concentration of
serum IgG, IgG2a, and B and T cell (CD4+ and CD8+) populations in
vaccinated animals compared to control animals (p < 0.001).
* Vaccinated animals demonstrated five times more tumor suppression
than control animals, confirming the immune response activation and
protection (p < 0.001).
Conclusion:
* The research suggests a potential pathway for individualized
immunotherapy following surgical tumor removal to prolong relapse
episodes.
Click here for Full Text (PDF)
2018
41. Tanja Ilić, Sanela Savić, Bojan Batinić, Bojan Marković, Markus
Schmidberger, Dominique Lunter, Miroslav Savić, Snežana Savić,
Combined use of biocompatible nanoemulsions and solid microneedles
to improve transport of a model NSAID across the skin: In vitro and
in vivo studies, European Journal of Pharmaceutical Sciences, Volume
125, 2018, Pages 110-119.
Click here for Full Text (PDF)
40. Olatunji, O., Olubowale, M. & Okereke C., Microneedle-assisted
transdermal delivery of acetylsalicylic acid (aspirin) from
biopolymer films extracted from fish scales, C. Polym. Bull. (2018)
75: 4103.
Click here for Full Text (PDF)
2017
39. C. Uppuluri, J. Devineni, T. Han, A. Nayak, K. J. Nair, B. R.
Whiteside, D. B. Das, B. N. Nalluri, Microneedle-assisted
transdermal delivery of Zolmitriptan: effect of microneedle
geometry, in vitro permeation experiments, scaling analyses and
numerical simulations, Drug Development and Industrial Pharmacy
(2017), Volume 43, Number 8, pp. 1292-1303.
AdminMed's Note: There are several following issues in this
publication:
* AdminPatch microneedle arrays have 1 cm2 active area in contrast
to this publication incorrectly referencing 1.77 cm2 active area;
* AdminPatch 1200 has 43 (forty-three) microneedles located within 1
cm2 circular area while the publication incorrectly says that
AdminPatch 1200 has 41 microneedles per 1.77 cm2;
* AdminPatch microneedle arrays have 3D hollow microneedle shape and
not “Flat (2D)” as reported in this publication. AdminPatch
microneedle and base thicknesses are incorrectly measured in this
publication as well.
* The correct Reference 21 should be: Vadim V. Yuzhakov, Microneedle
array, patch, and applicator for transdermal drug delivery, US
Patent No. 7,658,728. Washington DC: U.S.Patent and Trademark
Office; 2010.
Click here for Full Text (PDF)
38. B. N. Nalluri, C. Uppuluri, J. Devineni, A. Nayak, K. J. Nair,
B. R. Whiteside, D. B. Das, Effect of microneedles on transdermal
permeation enhancement of amlodipine, Drug Deliv. and Transl. Res.
(2017) 7:383–394.
AdminMed's Note: There are several following issues in this
publication:
* AdminPatch microneedle arrays have 1 cm2 active area in contrast
to this publication incorrectly referencing 1.77 cm2 active area;
* AdminPatch 1200 has 43 (forty-three) microneedles located within 1
cm2 circular area while the publication incorrectly says that
AdminPatch 1200 has 41 microneedles per 1.77 cm2;
* AdminPatch microneedle arrays have 3D hollow microneedle shape and
not “Flat (2D)” as reported in this publication. AdminPatch
microneedle and base thicknesses are incorrectly measured in this
publication as well.
* The correct Reference 23 should be: Vadim V. Yuzhakov, Microneedle
array, patch, and applicator for transdermal drug delivery, US
Patent No. 7,658,728. Washington DC: U.S.Patent and Trademark
Office; 2010.
Click here for Full Text (PDF)
37. P.-C. Hsu, C. Liu, A. Y. Song, Z. Zhang, Y. Peng, J. Xie, K.
Liu, C.-L. Wu, P. B. Catrysse, L. Cai, S. Zhai, A. Majumdar, S. Fan,
Y. Cui, A dual-mode textile for human body radiative heating and
cooling. Sci. Adv. 3, e1700895 (2017).
Click here for Full Text (PDF)
36. M. Gkikas, R. K. Avery, C. E. Mills, R. Nagarajan, E. Wilusz, B.
D. Olsen, Hydrogels That Actuate Selectively in Response to
Organophosphates, Adv. Funct. Mater. 2017, 27, 1602784.
Click here for Full Text (PDF)
35. Uppuluri, C., Shaik, A., Han, T. et al., Effect of Microneedle
Type on Transdermal Permeation of Rizatriptan, AAPS PharmSciTech
(2017) 18: 1495.
Click here for Full Text (PDF)
2016
M. Gkikas, R. K. Avery, C. E. Mills, R.
Nagarajan, E. Wilusz, B. D. Olsen, Hydrogels That Actuate
Selectively in Response to Organophosphates, Adv. Funct. Mater.
2017, 27, 1602784.
Click here for Full Text (PDF)
Uppuluri, C., Shaik, A., Han, T. et al.,
Effect of Microneedle Type on Transdermal Permeation of Rizatriptan,
AAPS PharmSciTech (2017) 18: 1495.
Click here for Full Text (PDF)
Brendan Koch, Ilaria Rubino, Fu-Shi Quan,
Bongyoung Yoo, and Hyo-Jick Choi, Microfabrication for Drug
Delivery, Materials. 2016; 9(8):646
Click here for Full Text (PDF)
Suprita A. Tawde, Lipika Chablani, Archana
Akalkotkar, Martin J. D'Souza, Evaluation of microparticulate
ovarian cancer vaccine via transdermal route of delivery, Journal of
Controlled Release, Volume 235, August 2016, Pages 147-154
Click here for Full Text (PDF)
Buchi Naidu Nalluri, Sirivalli Kosuri, Sai Sri
Anusha Valluru, Chandra Teja Uppuluri, Ashraf Sultana Shaik,
Microneedle Assisted Transdermal Delivery of Levodopa, Indian
Journal of Pharmaceutical Education and Research., 2016;
50(2):287-294
Click here for Full Text (PDF)
Jennifer Zhang, Yan Wang, Jane Y. Jin, Simone
Degan, Russell P. Hall, Ryan D. Boehm, Panupong Jaipan, Roger J.
Narayan, Use of Drawing Lithography-Fabricated Polyglycolic Acid
Microneedles for Transdermal Delivery of Itraconazole to a Human
Basal Cell Carcinoma Model Regenerated on Mice, JOM, April 2016,
Volume 68, Issue 4, pp 1128-1133
Click here for Full Text (PDF)
2015
Leeladurga, V, Teja, UC, Sultana, SKA, Sudeep,
K, Anusha, VSS, Han, T, Nalluri, BN, Das, DB, Application of
Microneedle Arrays for Enhancement of Transdermal Permeation of
Insulin: In Vitro Experiments, Scaling Analyses and Numerical
Simulations, AAPS PharmSciTech, 2015.
Click here for Full Text (PDF)
Naresh Modepalli, HN Shivakumar, KL Paranjothy
Kanni, and S Narasimha Murthy, Transdermal iron replenishment
therapy, Therapeutic Delivery, 2015, Vol. 6, No. 6, Pages 661-668.
Click here for Full Text (PDF)
Ololade Olatunji, Richard T. Olsson,
Microneedles from Fishscale-Nanocellulose Blends Using Low
Temperature Mechanical Press Method, Pharmaceutics, 2015, 7(4),
363-378;
Click here for Full Text (PDF)
Hiep X. Nguyen, Ajay K. Banga, Enhanced skin
delivery of vismodegib by microneedle treatment, Drug Delivery and
Translational Research, August 2015, Volume 5, Issue 4, pp 407-423.
Click here for Full Text (PDF)
Karmen Cheung, Geoff West, Diganta Bhusan Das,
Delivery of large molecular protein using flat and short
microneedles prepared using focused ion beam (FIB) as a skin
ablation tool. Drug Delivery and Translational Research, August
2015, Volume 5, Issue 4, pp 462-467. DOI10.1007/s13346-015-0252-0
Click here for Full Text (PDF)
Nayak, A, Short, L, Das, DB (2015) Lidocaine
permeation from a lidocaine NaCMC:gel microgel formulation in
microneedle pierced skin: vertical (depth averaged) and horizontal
permeation profiles, Drug Delivery and Translational Research,
August 2015, Volume 5, Issue 4, pp 372-386.
DOI: 10.1007/s13346-015-0229-z
Click here for Full Text (PDF)
Ita, K. Transdermal Delivery of Drugs with
Microneedles—Potential and Challenges. Pharmaceutics 2015, 7,
90-105. doi:10.3390/pharmaceutics7030090
Click here for Full Text (PDF)
Nayak, A., Das, D. B., Chao, T. C. and Starov,
V. M. (2015), Spreading of a Lidocaine Formulation on Microneedle-Treated
Skin. J. Pharm. Sci.. doi: 10.1002/jps.24625
Click here for Full Text (PDF)
Tao Han and Diganta Bhusan Das, "A New
Paradigm for Numerical Simulation of Microneedle-Based Drug Delivery
Aided by Histology of Microneedle-Pierced Skin," Journal of
Pharmaceutical Sciences (2015)
Click here for Full Text (PDF)
Atul Nayak, Hiten Babla, Tao Han, and Diganta
Bhusan Das, "Lidocaine carboxymethylcellulose with gelatine
co-polymer hydrogel delivery by combined microneedle and
ultrasound," Drug Delivery (2015)
Click here for Full Text (PDF)
Buchi N. Nalluri, V Sai Sri Anusha, R Sri
Bramhini, J Amulya, S K Ashraf Sultana, U Chandra Teja and Digantha
B. Das, "In Vitro Skin Permeation Enhancement of Sumatriptan by
Microneedle Application" (2015), http://dx.doi.org/10.2174/1567201812666150304123150
http://www.eurekaselect.com/129118/article
2014
Zhang, Dongwei, Diganta B. Das, and Chris D. Rielly.
"Microneedle Assisted Micro‐Particle Delivery from Gene Guns:
Experiments Using Skin‐Mimicking Agarose Gel." Journal of
pharmaceutical sciences (2014).
Full Text (PDF)
Monika Kaur, Kevin B. Ita, Inna E. Popova, Sanjai J.
Parikh, Daniel A. Bair, Microneedle-assisted delivery of verapamil
hydrochloride and amlodipine besylate, European Journal of
Pharmaceutics and Biopharmaceutics.
Full Text (PDF)
Cheung, K, Han, T, Das, DB. "Effect of Force of
Microneedle Insertion on the Permeability of Insulin in Skin,"
Journal of Diabetes Science and Technology (2014).
Full Text (PDF)
Dongwei Zhang, Chris D. Rielly, and Diganta B. Das.
"Microneedle-assisted microparticle delivery by gene guns:
experiments and modeling on the effects of particle
characteristics," Drug Delivery (2014).
Full Text (PDF)
Dongwei Zhang, Diganta B. Das, Chris D. Rielly.
"Microneedle assisted micro-particle delivery by gene guns:
Mathematical model formulation and experimental verification,"
Chemical Engineering Science (2014).
Full Text (PDF)
Dongwei Zhang, Diganta B. Das, "Microneedle assisted
microparticle delivery: experiments using a skin mimicking agarose
gel. The Third International Conference on Microneedles 2014,
University of Maryland School of Pharmacy in Baltimore, Maryland,
19th-21st May 2014, pp. 67-68.
Full Text (PDF)
2013
Singh, Neha D., and Ajay K. Banga.
"Controlled delivery of ropinirole hydrochloride through skin using
modulated iontophoresis and microneedles." Journal of drug targeting
21.4 (2013): 354-366.
Full Text (PDF)
Atul Nayak, Diganta B. Das, Goran
T. Vladisavljević,
"Microneedle-Assisted Permeation of Lidocaine Carboxymethylcellulose
with Gelatine Co-polymer Hydrogel." Pharmaceutical Research,
November 2013.
Full Text (PDF)
Ita, Kevin, Nanik Hatsakorzian, and Vladimir
Tolstikov. "Microneedle-Mediated Delivery of Atenolol and Bisoprolol
Hemifumarate." Journal of Nanopharmaceutics and Drug Delivery 1.1
(2013): 38-44.
Full Text (PDF)
Juluri, Abhishek, et al. "Minimally invasive
transdermal delivery of iron–dextran." Journal of pharmaceutical
sciences 102.3 (2013): 987-993.
Full Text (PDF)
Tao Han, Diganta B. Das, "Permeability Enhancement
for Transdermal Delivery of Large Molecule Using Low-Frequency
Sonophoresis Combined with Microneedles." Journal of Pharmaceutical
Sciences, Vol. 102, 3614–3622 (2013).
Full Text (PDF)
Zhang, Dongwei, Diganta B. Das, and Chris D. Rielly.
"An Experimental Study of Microneedle‐Assisted Microparticle
Delivery." Journal of pharmaceutical sciences 102.10 (2013):
3632-3644.
Full Text (PDF)
Wenchao Sun, Zeynep Araci, Mohammed Inayathullah,
Sathish Manickam, Xuexiang Zhang, Marc A. Bruce, M. Peter
Marinkovich, Alfred T. Lane, Carlos Milla, Jayakumar Rajadas, Manish
J. Butte, Polyvinylpyrrolidone microneedles enable delivery of
intact proteins for diagnostic and therapeutic applications, Acta
Biomaterialia, Volume 9, Issue 8, August 2013, Pages 7767-7774.
Full Text (PDF)
Yuen, Clement, and Quan Liu. "Towards in vivo
intradermal surface enhanced Raman scattering (SERS) measurements:
silver coated microneedle based SERS probe." Journal of biophotonics
(2013).
Full Text (PDF)
Yuen, Clement, and Quan Liu. "Ag coated microneedle
based surface enhanced Raman scattering probe for intradermal
measurements." European Conferences on Biomedical Optics.
International Society for Optics and Photonics, 2013.
Full Text (PDF)
2012
Modepalli, Naresh, et al.
"Microporation and ‘Iron’tophoresis for Treating Iron Deficiency
Anemia." Pharmaceutical research (2013): 1-10.
Full Text (PDF)
2011
Lipika Chablani, Suprita Tawde,
Archana Akalkotkar and Martin J. D’Souza, Formulation of Novel
Particulate Breast Cancer Vaccines using Spray Drying and In Vivo
Evaluation of Vaccine Efficacy.
Full Text (PDF)
2010
A paper about AdminPen devices
was published in Drug Delivery Technology.
A well-known journal Drug Delivery Technology recently published our
paper describing AdminPen devices. Please click on the following
link to read the published paper about AdminPen devices and the
enabling AdminPatch microneedle technology:
Yuzhakov, Vadim V. "The AdminPenTM Microneedle Device for Painless &
Convenient Drug Delivery." Drug Deliv. Technol 10.4 (2010): 32-36.
Full Text (PDF)
2007
V. V. Yuzhakov, “Advanced micro-needle Patch (AdminPatch™) for Minimally Invasive Transdermal Drug Delivery,” Invited Presentation at 1st Annual Skin Summit: Transdermal Drug Delivery & Development & Beyond, Philadelphia, PA, February 22-23, 2007.